Quinine Tolerance in Pregnancy

Sir,?The above article in the December 1937 issue interested me very much because it raises some other points. The patient was given nine 10-grain quinine injections intramuscularly,. thrice daily and on consecutive days. In the London School of Tropical Medicine and Hygiene they condemn most emphatically intramuscular injections of quinine. They say quinine causes tissue necrosis, much of the quinine remains unabsorbed, at least for a very long time, because of the necrosis the site remains painful, occasionally tetanus develops and abscess formation is fairly frequent. TheV teach that if quinine is to be given parenterally, ft must be given intravenously. I presume, all the injections were given intragluteally. It would be interesting to know what was the attitude of the patient towards the injections. I have no experience in this method, because, knowing that it is painful, I always use intravenous method whenever quinine by injections is indicated; I guess, however, that it would be difficult to find ten painless sites in such a short period. In the particular case, when it was decided to giv?